A 65-year-old woman was addressed to the Department of Radiology for assessment of dementia. Mnesic tests found moderate memory problems with mini-mental state (MMS) measured at 23/30. Symptoms were essentially marked by behavioral disorders of gradual onset for 2 years (decline in activity and empathy for her family). She was addressed for assessment of Alzheimer’s type dementia. MRI examination (coronal and sagittal T1 weighted sequences) found a severe asymmetrical cortico subcortical atrophy dominant at the right frontal lobe and anterior portion of right temporal lobe (Fig. A and B, white arrows). Hippocampal regions were preserved (Fig. A, asterix). The diagnosis of frontotemporal lobar dementia (FTLD) was therefore suggested.